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What is Regenerative Injection Therapy?

Regenerative Injection Therapy is therapy that harnesses and stimulates the body’s own healing and regenerative processes to restore function lost due to injury, age, or overuse. Depending on the individual patient, severity of pain, and location of the injury, these healing properties are stimulated with perineural injection therapy, prolotherapy, platelet rich plasma (PRP), or exosomes.

What is Enovative Wellness’s approach to Regenerative Injection Therapy?

Enovative Wellness is committed to delivering the highest quality regenerative injection therapy to achieve the highest level of treatment success. To honor this commitment, Enovative Wellness approaches regenerative injection in a 4 Pillar approach:

Pillar 1: The Right Diagnosis

Before even discussing regenerative treatment options, Enovative Wellness staff takes the time to get a comprehensive and thorough understanding of what is causing pain or dysfunction in his patients. This also requires a thorough physical examination and, in many cases, diagnostic imaging including X-ray, MSK Ultrasound, or MRI studies.

Pillar 2: The Right Healing Environment

At Enovative Wellness, we believe that a healthy body has the greatest potential for healing and regeneration. Conditions such as diabetes, hypertension, testosterone deficiency, hypothyroidism, adrenal fatigue, and systemic inflammation can adversely affect the success of regenerative injections. These conditions may need to be addressed before or during the course of your injection therapy.

Pillar 3: The Right Injection Solution

Just as each patient has a unique injury history, each injection solution has unique properties and benefits. Whether it’s the dextrose concentration of prolotherapy, the platelet concentration of PRP, or the number of billions of exosomes, each variable can affect the success of your treatment. Enovative Wellness works with each patient to determine which injection solution is the most effective option given the patients injury severity, treatment goals, lifestyle, and budget.

Pillar 4: The Right Location

Injecting regenerative injection solutions in the exact location of the injury is critical for treatment success. Enovative Wellness staff will perform the majority of regenerative injection treatments under ultrasound guidance (MSK Ultrasound) being operated by an experienced and licensed technician.

Enovative Wellness’s approach to Regenerative Injection Therapy

What types of Regenerative Injection Therapy
does Enovative Wellness offer?

Perineural Injection Therapy

Perineural Injection Therapy consists of a series of small injections of buffered low concentration (5-10%) dextrose under the skin to treat painful areas where nerves are inflamed.

These injections act directly on the nerve membranes to immediately decrease nerve inflammation. This not only relieves pain but allows the nerve to function better and heal underlying injuries.

Most injuries, whether related to muscles, tendons or joints have some component of nerve dysfunction. Treating the superficial and deep nerves related to the underlying injury can help accelerate healing and relieve pain.

Additionally, chronic nerve pain is often due to nerve compression secondary to trauma, arthritis, sports, overuse, occupational, and surgical injuries and this therapy may also this compression.


Prolotherapy is a regenerative therapy where a mild irritant solution of dextrose, local anesthetic, and Vitamin B12 is injected into joints and where injured ligaments and tendons attach to bone.

This dextrose solution is injected to induce a local inflammatory response that reactivates the immune system to promote the body’s natural healing cascade.

Sprains and strains can become chronic when our body’s natural healing process is insufficient to result in normal tensile strength or tightness after an injury.

This insufficiency, known as ligament laxity, leads to pain, instability, and degeneration. By reinitiating our body’s healing cascade with prolotherapy, these difficult to heal areas may repair, strengthen and tighten over time.

Additionally, prolotherapy has been shown to regenerate and repair damaged cartilage, reduce pain and improve functioning in patients with osteoarthritis. (Note: Prolotherapy will not regrow cartilage if it is completely absent in the joint)

Platelet Rich Plasma (PRP)

Platelet rich plasma (PRP) is a regenerative injection therapy that re-introduces your own concentrated blood platelets into injured soft tissue, tendons, and ligaments or joints with chronic deterioration.

PRP consists of having a small sample of your blood drawn then spun in centrifuge to concentrate your platelets. This concentrated PRP containing a high concentration of growth factors is injected into an injured area or arthritic joint to initiate your body’s natural repair processes.

Additionally, PRP attracts your body’s own stem cells to further promote repair and rebuilding of damaged tissue.

For these reasons, PRP injections may accelerate the body’s natural healing ability leading to a faster, more efficient restoration of the injured tissue to a healthy state.


Exosomes are extracellular vesicles, or small bubbles, that are released from cells. These exosomes carry Proteins, growth factors, mRNA, and MiRNA.

Exosomes act as cell-to-cell communication vehicles, transporting molecules that are important regulators of intracellular information between close and distant cells.

They carry information from place to place with different functions and purposes telling cells how and when to react.

By utilizing Exosomes from Stem Cells and rich bioactive sources we can signal our own cells to help them restore proper function, modulate inflammation, decrease pain, and regenerate diseased, aged, or damaged tissues.

Exosomes allow us to take advantage of the engine behind stem cell therapy without the risk of rejection (If Donor cells) and the issue of low cell survival in stem cell treatments (Autologous & Donor).

Research has given us a valuable insight into the practical functionality of exosomes. It was shown that if we expose the stem cells of an older organism to those of a younger organism, we see that exosomes from the young stem cells are responsible for rejuvenating the older cells. This healing mechanism can now be used in regenerative medicine.

What conditions benefit from regenerative injection therapy?

Injuries including but not limited to:

  • Shoulder pain (arthritis and rotator cuff tears)
  • Tennis and Golfer’s Elbow
  • Osteoarthritis of the wrist and hand
  • Knee pain (arthritis, meniscus tears, ACL, LCL, and MCL injury)
  • Hip pain (arthritis and bursitis)
  • Low Back Pain, Sciatica and SI joint pain
  • Ankle sprains
  • Achilles tendonitis
  • Cervical arthritis, pain, and injury
  • Ligament and Tendon injury

Depending on the severity of your injury and response to treatment, you may need a series of regenerative injections treatments to achieve the most effective results.

Because each condition and patient are different, there is no guarantee of how fast the results will be achieved. Some patients have seen results within a few days; however, it may take up to as long as nine months to see results.

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